Updates

Adult Stem Cells Show Anti-Aging Potential

APRIL 02, 2018

Longeveron-Grown Stem Cells Advance on Aging Frailty and Related Disabilities Gail Dutton Longeveron’s co-founder and CSO Joshua M. Hare, M.D. (shown here), proposes that mesenchymal stem cells may counter aging frailty. “Frailty is not an inevitable effect of aging but can be thought of as unsuccessful aging and an increased vulnerability to stressors,” Dr. Hare […]

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This Anti-Aging Injection Might Actually Work

MARCH 22, 2018

Karen Weintraub  Follow Health/Science journalist passionate about human health, cool research and great storytelling. Mar 22 Stem cells are overhyped as a cure for everything. But they‘re finally showing promise in making elderly people stronger. Illustration by Thomas Hedger Phillip George golfs regularly, works out on a treadmill, and lifts a few weights — “not body building, […]

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Stem cells could boost this Maryland baby’s heart and chance for a normal life

MARCH 13, 2018

http://www.baltimoresun.com/health/96102780-132.html  Meredith Cohn Contact Reporter The Baltimore Sun Surgeons trying a new way to save the life of a baby born with half a heart stood over her open chest and waited for the FedEx box. Doctors in Miami had overnighted two small vials of stem cells to the University of Maryland Medical Center. Now the Baltimore […]

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First Longeveron Mesenchymal Stem Cell Treatment Administered to an Infant with Rare Heart Condition as Part of Groundbreaking Clinical Trial

FEBRUARY 27, 2018

NEWS PROVIDED BY Longeveron LLC  Feb 27, 2018, 14:57 ET SHARE THIS ARTICLE MIAMI, Feb. 27, 2018 /PRNewswire/ — Longeveron announced that its pioneering clinical trial to treat infants with Hypoplastic Left Heart Syndrome officially started with the first patient receiving the company’s mesenchymal stem cell therapy in a procedure performed at the University of Maryland Medical Center in Baltimore. Hypoplastic Left […]

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Regenerative medicine conference points to new research opportunities

JANUARY 31, 2018

January 31, 2018 Candace KERR, Health Scientist Administrator, Division of Aging Biology (DAB). Funding Opportunities Meetings Research Among the initiatives launched under the 21st Century Cures Act, which brought us the Cancer Moonshot, the BRAIN initiative, and the All of Us precision medicine program, is the Regenerative Medicine Innovation Project (RMIP). NIH, in coordination with the Food […]

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Longeveron Shares Promising State of Regenerative Medicine Research with Experts at the FDA, NIH and Other Leading Organizations at National Conference

JANUARY 23, 2018

Longeveron Shares Promising State of Regenerative Medicine Research with Experts at the FDA, NIH and Other Leading Organizations at National Conference NEWS PROVIDED BY Longeveron LLC  09:00 ET MIAMI, Jan. 23, 2018 /PRNewswire/ — The early results of mesenchymal stem cells studies look encouraging for lessening or reversing the effects of Aging Frailty, Joshua M. Hare, M.D., Director of the […]

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Longeveron to Play Prominent Role at the World Stem Cell Summit in Miami

JANUARY 22, 2018

Company will Host Events and Contribute Regenerative Medicine Expertise NEWS PROVIDED BY Longeveron LLC  Jan 22, 2018, 10:28 ET MIAMI, Jan. 22, 2018 /PRNewswire/ — Longeveron LLC, regenerative medicine company, announced that it will help roll out the red carpet when investigators from around the globe converge on the company’s hometown of Miami for the 2018 World Stem Cell Summit, January 22-26 at […]

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Longeveron developing stem cell treatments for Frailty, Alzheimers and other aging diseases

JANUARY 17, 2018

brian wang | January 17, 2018 Longeveron is a life sciences company developing biological solutions for aging and aging-associated diseases through the use of Allogeneic Human Mesenchymal Stem Cells, harvested and grown at our facility in Miami, Florida, from adult-donor bone marrow. Longeveron is a privately funded startup. The Longeveron-grown Mesenchymal Stem Cells (LMSCs) are multipotent stem cells. […]

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NIH Awards Longeveron Cutting-Edge Research Grant to Fight ‘Metabolic Syndrome’ of Obesity, High Blood Pressure, Unhealthy Cholesterol and More through Regenerative Medicine

JANUARY 09, 2018

  NEWS PROVIDED BY Longeveron  09:42 ET MIAMI, Jan. 9, 2018 /PRNewswire/ — New advances in regenerative medicine could improve the odds for a healthier life for people with metabolic syndrome. The National Institutes of Health’s National Institute on Aging (NIA) recognized this, and recently awarded a prestigious research grant to Longeveron, a regenerative medicine therapy company based […]

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Longeveron Pioneering Development of Stem Cell Therapies for Aging Frailty

DECEMBER 21, 2017

  Published: Dec 21, 2017 MIAMI, Fl., Dec. 18, 2017 – Longeveron, a leading life sciences company developing innovative therapies for age-related diseases, announced that the company is progressing with the development of its stem cell treatment to ameliorate aging frailty.  The company is building on Phase 1 safety and Phase 2 safety, tolerability and efficacy […]

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A Landmark Stem Cell Therapy Shows Striking Results Against Aging

OCTOBER 30, 2017

  Two clinical trials have shown that Mesenchymal stem cells (MSCs) are safe and highly effective in treating age-related frailty. Buoyed by the success of their initial trials, scientists from the University of Miami’s Miller School of Medicine are now moving their research into larger trials. Once these steps have been completed, the stem cell-based […]

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One Last Question Before the Operation: Just How Frail Are You?

OCTOBER 27, 2017

One Last Question Before the Operation: Just How Frail Are You? Paula Span THE NEW OLD AGE OCT. 27, 2017 Earlier this month, Dr. Thomas Robinson, a general surgeon at the Denver Veterans Affairs Medical Center, saw a patient in his mid 80s. The man had gallstones that caused infections, with abdominal pain severe enough to […]

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University Of Miami Miller School of Medicine: Stem Cell Studies Build Momentum toward Therapy for Age-Associated Frailty

OCTOBER 23, 2017

Buoyed by promising results of a Phase I study demonstrating the safety of mesenchymal stem cell therapy to treat frailty in older adults, researchers at the Interdisciplinary Stem Cell Institute (ISCI) at the University of Miami Miller School of Medicine have taken it a step further. Now Phase II randomized, placebo-controlled trial findings have verified […]

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Miami Herald: Stem cell infusions improved health in frail elderly, UM researchers say

OCTOBER 20, 2017

Dr. Joshua Hare, director of the University of Miami’s Interdisciplinary Stem Cell Institute, conducts research in the lab at the UM Miller School of Medicine. Hare recently co-authored a study published in the Journals of Gerontology that found stem cell infusion therapy helped to improve lung function and physical ability in frail elderly patients. PATRICK FARRELL MIAMI […]

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Longeveron Pioneering Development of Stem Cell Therapies for Aging Frailty

OCTOBER 17, 2017

Longeveron LLC, a leading life sciences company developing innovative therapies for age-related diseases, announced that the company is progressing with the development of its stem cell treatment to ameliorate aging frailty.  The company is building on Phase 1 safety and Phase 2 safety, tolerability and efficacy studies conducted by the University of Miami Miller School of Medicine […]

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US News and World Report: Stem Cells May Hold the Fix

OCTOBER 04, 2017

Believe it or not, the cure to what ails you could already be inside you. Welcome to the dawning world of stem cell therapy, in which researchers are exploring the possibilities of growing new body parts and healing old ones by using patients’ own stem cells. The idea is that these unspecialized cells (which can […]

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Longeveron Initiates Phase 2b Stem Cell Therapy Trial to Treat Aging Frailty

SEPTEMBER 07, 2017

Longeveron LLC, a regenerative medicine company developing cellular therapies, announced today that it treated its first patient in the Company’s Phase 2b clinical trial evaluating the safety and efficacy of Longeveron human Allogeneic Mesenchymal Stem Cells (LMSCs) in patients with Aging Frailty Syndrome. This trial is being conducted pursuant to an Investigational New Drug Application […]

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Statement from FDA Commissioner Scott Gottlieb, M.D. on the FDA’s new policy steps and enforcement efforts to ensure proper oversight of stem cell therapies and regenerative medicine

AUGUST 28, 2017

FDA Statement Statement from FDA Commissioner Scott Gottlieb, M.D. on the FDA’s new policy steps and enforcement efforts to ensure proper oversight of stem cell therapies and regenerative medicine For Immediate Release August 28, 2017 Statement One of the most promising new fields of science and medicine is the area of cell therapies and their […]

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Longeveron to Sponsor Industry Symposium on Regenerative Medicine at 2017 IAGG World Congress

JULY 21, 2017

Longeveron LLC is sponsoring a regenerative medicine symposium at the 2017 International Association of Gerontology and Geriatrics (IAGG) World Congress on July 25 in San Francisco.  The symposium, titled Regenerative Medicine Alternatives for Aging Conditions, will feature a global panel of physicians who are experts in stem cell therapy and geriatric conditions, such as Aging […]

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Longeveron to Receive Grant from the Maryland Stem Cell Research Fund

MAY 22, 2017

MIAMI, Fl., May 22, 2017 – Longeveron announced receiving a $750,000 grant from the Maryland Stem Cell Research Fund (MSCRF) to continue groundbreaking stem cell research.  Longeveron, a Miami based regenerative medicine company, will partner with the University of Maryland and Johns Hopkins University to conduct a clinical trial for Hypoplastic Left Heart Syndrome (HLHS), […]

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Longeveron Announces Publication of Phase 1 Safety and Efficacy Trial Results for Allogeneic Stem Cell Treatment in Frailty Patients

MAY 15, 2017

MIAMI, Fl., May 15, 2017 – Longeveron LLC, a leading regenerative medicine company developing innovative therapies for age-related diseases, announced the publication of Phase 1 safety, tolerability and efficacy data of its proprietary allogeneic mesenchymal stem cell (MSC) product in patients with Aging Frailty. The results were published on April 21st online in the Journals […]

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Longeveron Begins Enrollment of Second Cohort of Phase 1 Trial of Allogeneic Mesenchymal Stem Cells to Treat Alzheimer’s Disease Patients

MAY 10, 2017

Data Monitoring Committee Confirms Safety and Recommends Trial Proceed   MIAMI, Fl., May 10, 2017 – Longeveron, a regenerative medicine company, today announced that their Phase 1 Alzheimer’s disease trial will proceed with enrollment at the recommendation of an independent Data Monitoring Committee (DMC) which reviewed data from the trial’s safety run-in phase. The clinical […]

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STEM CELLS SHOW PROMISE IN THE TREATMENT OF FRAILTY

APRIL 14, 2017

BARCELONA, SPAIN, April 28, 2017. Stem cells from healthy young donors, delivered via intravenous infusion to frail older adults, were shown to reduce inflammation in a small pilot study reported today at the International Conference on Frailty and Sarcopenia Research (ICFSR). These findings suggest that stem cells may have the potential to reverse some of […]

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Longeveron is Hosting a Satellite Symposium at the IAGG 2017 in San Francisco

APRIL 03, 2017

Longeveron’s symposium will be in Tuesday July 25 during lunch and will accommodate up to 125 attendees. This will include a panel presentation with some of the world experts on frailty. The theme for IAGG 2017, “Global Aging and Health: Bridging Science, Policy, and Practice,” will convene professionals from a variety of disciplines such as […]

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Longeveron will be speaking at the International Conference on Frailty and Sarcopenia Research

APRIL 03, 2017

Longeveron will be speaking at the International Conference on Frailty and Sarcopenia Research in Barcelona, Spain on April 27-29, 2017. Learn more

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Researchers Testing Stem Cells To Treat Alzheimer’s

APRIL 14, 2016

By Alexandria Hein In a first-of-its-kind clinical trial, researchers at the University of Miami Miller School of Medicine are using mesenchymal stem cells (MSCs) in an attempt to slow or reverse the symptoms of Alzheimer’s disease. The team is aiming to enroll 30 patients who will be tested and observed for cognitive function, memory, quality […]

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Publications

Stem Cell Transplantation for Frailty

The Journals of Gerontology, March 2017

LeCouteur 2017 Stem Cell Transplant for Frailty Guest Editorial

It was reported over 50 years ago that old age is associated with depletion and loss of function of stem cells (1). Since that time, there has been extensive research confirming the deleterious effects of aging on all types of stem cells, and a growing belief that such age-related changes in stem cells further accelerate tissue and organismal aging (2–4). There are two major divisions of stem cells, embryonic stem cells and adult stem cells.

 

Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo-Controlled Clinical Trial

The Journals of Gerontology, June 2017

Tompkins et al 2017 Allogeneic MSCs Ameliorate Aging Frailty-A Phase II Study

There is increasing recognition of the health burden of frailty, a syndrome that increases in incidence with aging. Frailty confers an increased vulnerability to adverse health outcomes and mortality in response to stressors (1,2). Of note, the frailty syndrome is driven mostly by biological aging processes that include inflammation and stem cell dysfunction, as opposed to chronological aging (2–5). Early intervention may improve quality of life, reduce hospitalizations,
and nursing home costs (6,7). Therefore, it is increasingly important
to recognize the clinical onset of frailty, and to develop effective therapeutic strategies.

Allogeneic Human Mesenchymal Stem Cell Infusions for Aging Frailty

Journals of Gerontology, March 2017

Golpanian et al 2017 CRATUS Allogeneic MSCs for Aging Frailty Phase 1

Impaired endogenous stem cell repair capacity is hypothesized to be a biologic basis of frailty. Therapies that restore regenerative capacity may therefore be beneficial. This Phase 1 study evaluated the safety and potential efficacy of intravenous, allogeneic, human mesenchymal stem cell (allo-hMSC)-based therapy in patients with aging frailty.