Updates

Dr. Joshua Hare To Present Longeveron Regenerative Stem Cell Research At The Sixth Annual Aspen BrainLab

JULY 13, 2018

NEWS PROVIDED BY Longeveron LLC 14:53 ET MIAMI, July 13, 2018 /PRNewswire/ — Longeveron LLC, a biopharmaceutical company that develops stem cell therapies for aging-related diseases, announced that Dr. Joshua Hare, Chief Science Officer, will present at the sixth annual Aspen BrainLab on July 14.  Aspen BrainLab brings together leading scientists and medical experts in neurology and is organized Read More

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Development of Stem Cell Therapies for Aging-related Conditions

JUNE 21, 2018

Health Professional Radio Dr. Joshua Hare, MD, co-founder and Chief Science Officer of biotech company Longeveron, and founding director of the Interdisciplinary Stem Cell Institute at the University of Miami Miller School of Medicine, discusses two published positive clinical studies of stem cell treatment for aging frailty and how Longeveron is progressing with development of stem Read More

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‘Longest Day’ honors Alzheimer’s sufferers and caregivers

JUNE 19, 2018

By Steve Dorfman, Palm Beach Post Staff Writer For family caregivers of Alzheimer’s sufferers, the disease is heartbreaking — and exhausting. It’s a perpetual ‘round-the-clock challenge — one that some studies say is responsible for 40 percent of family caregivers dying before the recipient of said care. To bolster hope and support for all those affected by Read More

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Longeveron Recruiting for Stem Cell Alzheimer’s Trial in South Florida

MAY 23, 2018

NEWS PROVIDED BY Longeveron LLC  09:49 ET MIAMI, May 23, 2018 /PRNewswire/ — Longeveron LLC, a biopharmaceutical company that develops stem cell therapies for age-related diseases, announced that it is currently recruiting for a Phase 1 clinical trial to evaluate the safety and efficacy of its allogeneic Mesenchymal Stem Cells (MSCs) in patients with Alzheimer’s disease.  The randomized, Read More

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Maryland technology development agency awards grant to study stem cells for improving flu vaccine

MAY 22, 2018

By Meredith Cohn  Contact Reporter The Baltimore Sun May 22, 2018, 12:45 PM The Maryland Technology Development Corp. has awarded a $750,000 grant to Longeveron LLC, a Miami-based biopharmaceutical company, to study whether stem cells can make a better flu vaccine for seniors with a researcher from Johns Hopkins University School of Medicine. Dr. Sean Leng, an Read More

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Longeveron Receives TEDCO Grant to Fund Stem Cell Research

MAY 22, 2018

Grant will be applied to clinical trials studying stem cells to boost Flu vaccine immune response in older patients NEWS PROVIDED BY Longeveron LLC  May 22, 2018, 09:29 ET MIAMI, May 22, 2018 /PRNewswire/ — Longeveron LLC, a biopharmaceutical company that develops stem cell therapies for aging-related conditions, announced that it has received a $750,000 grant from the Maryland Technology Read More

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Adult Stem Cells Show Anti-Aging Potential

APRIL 02, 2018

Longeveron-Grown Stem Cells Advance on Aging Frailty and Related Disabilities Gail Dutton Longeveron’s co-founder and CSO Joshua M. Hare, M.D. (shown here), proposes that mesenchymal stem cells may counter aging frailty. “Frailty is not an inevitable effect of aging but can be thought of as unsuccessful aging and an increased vulnerability to stressors,” Dr. Hare Read More

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This Anti-Aging Injection Might Actually Work

MARCH 22, 2018

Karen Weintraub  Follow Health/Science journalist passionate about human health, cool research and great storytelling. Mar 22 Stem cells are overhyped as a cure for everything. But they‘re finally showing promise in making elderly people stronger. Illustration by Thomas Hedger Phillip George golfs regularly, works out on a treadmill, and lifts a few weights — “not body building, Read More

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Stem cells could boost this Maryland baby’s heart and chance for a normal life

MARCH 13, 2018

http://www.baltimoresun.com/health/96102780-132.html  Meredith Cohn Contact Reporter The Baltimore Sun Surgeons trying a new way to save the life of a baby born with half a heart stood over her open chest and waited for the FedEx box. Doctors in Miami had overnighted two small vials of stem cells to the University of Maryland Medical Center. Now the Baltimore Read More

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First Longeveron Mesenchymal Stem Cell Treatment Administered to an Infant with Rare Heart Condition as Part of Groundbreaking Clinical Trial

FEBRUARY 27, 2018

NEWS PROVIDED BY Longeveron LLC  Feb 27, 2018, 14:57 ET SHARE THIS ARTICLE MIAMI, Feb. 27, 2018 /PRNewswire/ — Longeveron announced that its pioneering clinical trial to treat infants with Hypoplastic Left Heart Syndrome officially started with the first patient receiving the company’s mesenchymal stem cell therapy in a procedure performed at the University of Maryland Medical Center in Baltimore. Hypoplastic Left Read More

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Regenerative medicine conference points to new research opportunities

JANUARY 31, 2018

January 31, 2018 Candace KERR, Health Scientist Administrator, Division of Aging Biology (DAB). Funding Opportunities Meetings Research Among the initiatives launched under the 21st Century Cures Act, which brought us the Cancer Moonshot, the BRAIN initiative, and the All of Us precision medicine program, is the Regenerative Medicine Innovation Project (RMIP). NIH, in coordination with the Food Read More

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Longeveron Shares Promising State of Regenerative Medicine Research with Experts at the FDA, NIH and Other Leading Organizations at National Conference

JANUARY 23, 2018

Longeveron Shares Promising State of Regenerative Medicine Research with Experts at the FDA, NIH and Other Leading Organizations at National Conference NEWS PROVIDED BY Longeveron LLC  09:00 ET MIAMI, Jan. 23, 2018 /PRNewswire/ — The early results of mesenchymal stem cells studies look encouraging for lessening or reversing the effects of Aging Frailty, Joshua M. Hare, M.D., Director of the Read More

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Longeveron to Play Prominent Role at the World Stem Cell Summit in Miami

JANUARY 22, 2018

Company will Host Events and Contribute Regenerative Medicine Expertise NEWS PROVIDED BY Longeveron LLC  Jan 22, 2018, 10:28 ET MIAMI, Jan. 22, 2018 /PRNewswire/ — Longeveron LLC, regenerative medicine company, announced that it will help roll out the red carpet when investigators from around the globe converge on the company’s hometown of Miami for the 2018 World Stem Cell Summit, January 22-26 at Read More

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Longeveron developing stem cell treatments for Frailty, Alzheimers and other aging diseases

JANUARY 17, 2018

brian wang | January 17, 2018 Longeveron is a life sciences company developing biological solutions for aging and aging-associated diseases through the use of Allogeneic Human Mesenchymal Stem Cells, harvested and grown at our facility in Miami, Florida, from adult-donor bone marrow. Longeveron is a privately funded startup. The Longeveron-grown Mesenchymal Stem Cells (LMSCs) are multipotent stem cells. Read More

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NIH Awards Longeveron Cutting-Edge Research Grant to Fight ‘Metabolic Syndrome’ of Obesity, High Blood Pressure, Unhealthy Cholesterol and More through Regenerative Medicine

JANUARY 09, 2018

  NEWS PROVIDED BY Longeveron  09:42 ET MIAMI, Jan. 9, 2018 /PRNewswire/ — New advances in regenerative medicine could improve the odds for a healthier life for people with metabolic syndrome. The National Institutes of Health’s National Institute on Aging (NIA) recognized this, and recently awarded a prestigious research grant to Longeveron, a regenerative medicine therapy company based Read More

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Longeveron Pioneering Development of Stem Cell Therapies for Aging Frailty

DECEMBER 21, 2017

  Published: Dec 21, 2017 MIAMI, Fl., Dec. 18, 2017 – Longeveron, a leading life sciences company developing innovative therapies for age-related diseases, announced that the company is progressing with the development of its stem cell treatment to ameliorate aging frailty.  The company is building on Phase 1 safety and Phase 2 safety, tolerability and efficacy Read More

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A Landmark Stem Cell Therapy Shows Striking Results Against Aging

OCTOBER 30, 2017

  Two clinical trials have shown that Mesenchymal stem cells (MSCs) are safe and highly effective in treating age-related frailty. Buoyed by the success of their initial trials, scientists from the University of Miami’s Miller School of Medicine are now moving their research into larger trials. Once these steps have been completed, the stem cell-based Read More

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One Last Question Before the Operation: Just How Frail Are You?

OCTOBER 27, 2017

One Last Question Before the Operation: Just How Frail Are You? Paula Span THE NEW OLD AGE OCT. 27, 2017 Earlier this month, Dr. Thomas Robinson, a general surgeon at the Denver Veterans Affairs Medical Center, saw a patient in his mid 80s. The man had gallstones that caused infections, with abdominal pain severe enough to Read More

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University Of Miami Miller School of Medicine: Stem Cell Studies Build Momentum toward Therapy for Age-Associated Frailty

OCTOBER 23, 2017

Buoyed by promising results of a Phase I study demonstrating the safety of mesenchymal stem cell therapy to treat frailty in older adults, researchers at the Interdisciplinary Stem Cell Institute (ISCI) at the University of Miami Miller School of Medicine have taken it a step further. Now Phase II randomized, placebo-controlled trial findings have verified Read More

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Miami Herald: Stem cell infusions improved health in frail elderly, UM researchers say

OCTOBER 20, 2017

Dr. Joshua Hare, director of the University of Miami’s Interdisciplinary Stem Cell Institute, conducts research in the lab at the UM Miller School of Medicine. Hare recently co-authored a study published in the Journals of Gerontology that found stem cell infusion therapy helped to improve lung function and physical ability in frail elderly patients. PATRICK FARRELL MIAMI Read More

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Longeveron Pioneering Development of Stem Cell Therapies for Aging Frailty

OCTOBER 17, 2017

Longeveron LLC, a leading life sciences company developing innovative therapies for age-related diseases, announced that the company is progressing with the development of its stem cell treatment to ameliorate aging frailty.  The company is building on Phase 1 safety and Phase 2 safety, tolerability and efficacy studies conducted by the University of Miami Miller School of Medicine Read More

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US News and World Report: Stem Cells May Hold the Fix

OCTOBER 04, 2017

Believe it or not, the cure to what ails you could already be inside you. Welcome to the dawning world of stem cell therapy, in which researchers are exploring the possibilities of growing new body parts and healing old ones by using patients’ own stem cells. The idea is that these unspecialized cells (which can Read More

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Longeveron Initiates Phase 2b Stem Cell Therapy Trial to Treat Aging Frailty

SEPTEMBER 07, 2017

Longeveron LLC, a regenerative medicine company developing cellular therapies, announced today that it treated its first patient in the Company’s Phase 2b clinical trial evaluating the safety and efficacy of Longeveron human Allogeneic Mesenchymal Stem Cells (LMSCs) in patients with Aging Frailty Syndrome. This trial is being conducted pursuant to an Investigational New Drug Application Read More

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Statement from FDA Commissioner Scott Gottlieb, M.D. on the FDA’s new policy steps and enforcement efforts to ensure proper oversight of stem cell therapies and regenerative medicine

AUGUST 28, 2017

FDA Statement Statement from FDA Commissioner Scott Gottlieb, M.D. on the FDA’s new policy steps and enforcement efforts to ensure proper oversight of stem cell therapies and regenerative medicine For Immediate Release August 28, 2017 Statement One of the most promising new fields of science and medicine is the area of cell therapies and their Read More

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Longeveron to Sponsor Industry Symposium on Regenerative Medicine at 2017 IAGG World Congress

JULY 21, 2017

Longeveron LLC is sponsoring a regenerative medicine symposium at the 2017 International Association of Gerontology and Geriatrics (IAGG) World Congress on July 25 in San Francisco.  The symposium, titled Regenerative Medicine Alternatives for Aging Conditions, will feature a global panel of physicians who are experts in stem cell therapy and geriatric conditions, such as Aging Read More

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Longeveron to Receive Grant from the Maryland Stem Cell Research Fund

MAY 22, 2017

MIAMI, Fl., May 22, 2017 – Longeveron announced receiving a $750,000 grant from the Maryland Stem Cell Research Fund (MSCRF) to continue groundbreaking stem cell research.  Longeveron, a Miami based regenerative medicine company, will partner with the University of Maryland and Johns Hopkins University to conduct a clinical trial for Hypoplastic Left Heart Syndrome (HLHS), Read More

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Longeveron Announces Publication of Phase 1 Safety and Efficacy Trial Results for Allogeneic Stem Cell Treatment in Frailty Patients

MAY 15, 2017

MIAMI, Fl., May 15, 2017 – Longeveron LLC, a leading regenerative medicine company developing innovative therapies for age-related diseases, announced the publication of Phase 1 safety, tolerability and efficacy data of its proprietary allogeneic mesenchymal stem cell (MSC) product in patients with Aging Frailty. The results were published on April 21st online in the Journals Read More

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Longeveron Begins Enrollment of Second Cohort of Phase 1 Trial of Allogeneic Mesenchymal Stem Cells to Treat Alzheimer’s Disease Patients

MAY 10, 2017

Data Monitoring Committee Confirms Safety and Recommends Trial Proceed   MIAMI, Fl., May 10, 2017 – Longeveron, a regenerative medicine company, today announced that their Phase 1 Alzheimer’s disease trial will proceed with enrollment at the recommendation of an independent Data Monitoring Committee (DMC) which reviewed data from the trial’s safety run-in phase. The clinical Read More

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STEM CELLS SHOW PROMISE IN THE TREATMENT OF FRAILTY

APRIL 14, 2017

BARCELONA, SPAIN, April 28, 2017. Stem cells from healthy young donors, delivered via intravenous infusion to frail older adults, were shown to reduce inflammation in a small pilot study reported today at the International Conference on Frailty and Sarcopenia Research (ICFSR). These findings suggest that stem cells may have the potential to reverse some of Read More

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Longeveron is Hosting a Satellite Symposium at the IAGG 2017 in San Francisco

APRIL 03, 2017

Longeveron’s symposium will be in Tuesday July 25 during lunch and will accommodate up to 125 attendees. This will include a panel presentation with some of the world experts on frailty. The theme for IAGG 2017, “Global Aging and Health: Bridging Science, Policy, and Practice,” will convene professionals from a variety of disciplines such as Read More

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Longeveron will be speaking at the International Conference on Frailty and Sarcopenia Research

APRIL 03, 2017

Longeveron will be speaking at the International Conference on Frailty and Sarcopenia Research in Barcelona, Spain on April 27-29, 2017. Learn more

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Researchers Testing Stem Cells To Treat Alzheimer’s

APRIL 14, 2016

By Alexandria Hein In a first-of-its-kind clinical trial, researchers at the University of Miami Miller School of Medicine are using mesenchymal stem cells (MSCs) in an attempt to slow or reverse the symptoms of Alzheimer’s disease. The team is aiming to enroll 30 patients who will be tested and observed for cognitive function, memory, quality Read More

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Publications

Stem Cell Transplantation for Frailty

The Journals of Gerontology, March 2017

LeCouteur 2017 Stem Cell Transplant for Frailty Guest Editorial

It was reported over 50 years ago that old age is associated with depletion and loss of function of stem cells (1). Since that time, there has been extensive research confirming the deleterious effects of aging on all types of stem cells, and a growing belief that such age-related changes in stem cells further accelerate tissue and organismal aging (2–4). There are two major divisions of stem cells, embryonic stem cells and adult stem cells.

 

Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo-Controlled Clinical Trial

The Journals of Gerontology, June 2017

Tompkins et al 2017 Allogeneic MSCs Ameliorate Aging Frailty-A Phase II Study

There is increasing recognition of the health burden of frailty, a syndrome that increases in incidence with aging. Frailty confers an increased vulnerability to adverse health outcomes and mortality in response to stressors (1,2). Of note, the frailty syndrome is driven mostly by biological aging processes that include inflammation and stem cell dysfunction, as opposed to chronological aging (2–5). Early intervention may improve quality of life, reduce hospitalizations,
and nursing home costs (6,7). Therefore, it is increasingly important
to recognize the clinical onset of frailty, and to develop effective therapeutic strategies.

Allogeneic Human Mesenchymal Stem Cell Infusions for Aging Frailty

Journals of Gerontology, March 2017

Golpanian et al 2017 CRATUS Allogeneic MSCs for Aging Frailty Phase 1

Impaired endogenous stem cell repair capacity is hypothesized to be a biologic basis of frailty. Therapies that restore regenerative capacity may therefore be beneficial. This Phase 1 study evaluated the safety and potential efficacy of intravenous, allogeneic, human mesenchymal stem cell (allo-hMSC)-based therapy in patients with aging frailty.

BIBLIOGRAPHY

Joshua Michael Hare, M.D., F.A.C.C., F.A.H.A.

BIBLIOGRAPHY

AGING

Articles:
1. Golpanian S, El-Khorazaty J, Mendizabal A, DiFede DL, Suncion V, Karantalis V, Fishman JE, Ghersin E, Balkan W, Hare JM. Effect of Aging on human Mesenchymal Stem Cell Therapy in Ischemic Cardiomyopathy Patients. J Am Coll Cardiol. 2015 Jan 20;65(2):125-32. doi:10.1016/j.jacc.2014.10.040.
2. Golpanian S, DiFede DL, Pujol MV, Lowery MH, Levis-Dusseau S, Goldstein BJ, Schulman IH, Longsomboon B, Wolf A, Khan A, Heldman AW, Goldschmidt-Clermont PJ, Hare JM. Rationale and design of the allogeneiC human mesenchymal stem cells (hMSC) in patients with aging fRAilTy via intravenoUS delivery (CRATUS) study: A phase I/II, randomized, blinded and placebo controlled trial to evaluate the safety and potential efficacy of allogeneic human mesenchymal stem cell infusion in patients with aging frailty. Oncotarget. 2016 Mar 15;7(11):11899-912. doi: 10.18632/oncotarget.7727.
3. Golpanian S, DiFede DL, Khan A, Schulman IH, Landin AM, Tompkins BA, Heldman AW, Miki R, Goldstein BJ, Mushtaq M, Levis-Dusseau S, Byrnes JJ, Lowery M, Natsumeda M, Delgado C, Saltzman R, Vidro-Casiano M, Pujol MV, Da Fonseca M, Oliva AA Jr, Green G, Premer C, Medina A, Valasaki K, Florea V, Anderson E, El-Khorazaty J, Mendizabal A, Goldschmidt-Clermont PJ, Hare JM. Allogeneic Human Mesenchymal Stem Cell Infusions for Aging Frailty. J Gerontol A Biol Sci Med Sci. 2017 Apr 21. Doi: 10.1093/gerona//glx056 [Epub ahead of print]
4. Tompkins B, Difede DL, Khan A, Landin AM, Schulman I, Pujol M, Heldman A, Miki R, Goldshmidt- Clermont P, Goldstein B, Mushtaq M, Levis-Dusseau S Byrnes J, Lowery M, Natsumeda M, Delgado C, Saltzman R, Vidro-Casiano M, Da Fonseca M, Golpanian S, Premer C, Medina A, Valasaki K, Florea V, Anderson E, El-Khorazaty J, Mendizabal A, Green G, Oliva A, Hare JM. Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A phase II randomized, double-blind, placebo controlled clinical trial. J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1513-1522. doi: 10.1093/gerona/glx137.

Book Chapter:
1. Tompkins BA, Landin AM, Florea V, Natsumeda M, Tieger AC, Balkan W, Schulman IH, Hare JM. Allogeneic Mesenchymal Stem Cells as a Treatment for Aging Frailty. Frailty and Sarcopenia.Published online 2017 Jul 17. doi:10.1093/gerona/glx137, PMCID: PMC5861900, PMID: 28977399, Inbook: Frailty and Sarcopenia – Onset, Development and Clinical Challenges.