Deborah Ascheim, MD
Deborah Ascheim, MD is a physician-executive and independent board director with over 30 years of clinical and executive experience advancing breakthrough therapies, including gene, cell, and biologics, for rare, ultra-rare, and common diseases across multiple indications. She brings deep expertise in clinical and regulatory strategy, drug, gene and cell therapy development, and trial design. She currently serves as the Fractional Chief Medical Officer at Rejuvenate Bio, Inc., a clinical stage biotech company developing gene therapies to treat age related diseases in humans and dogs. She is also the founder and president of d2a Ltd., through which she provides strategic clinical and product development consulting across gene and cell therapies, small molecules, pharmaceuticals, and diagnostic and therapeutic devices. Prior to founding d2a Ltd., Dr. Ascheim served as Chief Medical Officer for StrideBio, Inc., a gene therapy company developing innovative genetic medicines for patients with devastating conditions. Dr. Ascheim previously served as the Chief Medical Officer for Capricor Therapeutics Inc., a NASDAQ-listed company, where she led all clinical development, regulatory affairs, clinical operations, and pharmacovigilance functions, overseeing multiple randomized controlled trials across cardiovascular and Duchenne muscular dystrophy indications and driving the company’s successful pivot to a rare disease focus. Dr. Ascheim’s clinical career was focused on heart failure cardiology. She trained and practiced at New York-Presbyterian/Columbia University Medical Center, where she was a faculty member in the Heart Failure Center for almost 15 years. She subsequently joined the Icahn School of Medicine at Mount Sinai as a Professor of Medicine and Vice-Chair of the Department of Population Health Science & Policy. She has three decades of experience as a clinical researcher and trialist, serving either as the Principal Investigator or other leadership role on NIH funded and industry trials totaling more than $140 million. She has served on multiple Data Safety Monitoring Boards, Clinical Events Committees, and trial Steering Committees, and has co-authored publications in leading journals including the New England Journal of Medicine, The Lancet, and Circulation. Dr. Ascheim has served on the Board of Directors for Physicians for Human Rights for many years including serving as the Vice Chair and subsequently Chair of the Board of Directors, the Chair of its Nominating & Governance Committee, and a longstanding member of the Executive Committee. She also served for a decade on the Board of Trustees of the Brearley School, where she chaired the Trusteeship & Governance Committee and the Education Committee and served on the Executive Committee. Dr. Ascheim earned her B.A. from Wellesley College and her M.D. from NYU Grossman School of Medicine.